TTP vs HUS

Thrombotic thrombocytopenic purpura sixtet:

1. fever
2. thrombocytopenia
3. microangiopathic hemolytic anemia (MAHA)
4. transient neurological deficits (seizures,hemiparesis, decrease consciousness,decrease vision)
5. proteinuria/hematuria
6. renal failure

hemolytic uremic anemia

MAHA + thrombocytopenia + dominant renal failure

NO neurological symptoms

often occur in childhood ( TTP mostly occurs in adult women)

triggers in HUS ---- verotoxin by E.coli O157 ( TTP has not been identified)